Geplaatst door: ACHROM

Hilicon is a leading company in developing and manufacturing hydrophilic interaction liquid chromatography (HILIC) products for the separation of polar and hydrophilic compounds. It has recently started to expand its iHILIC-Fusion and iHILIC‑Fusion(+)product lines into a 1 mm microbore column format.

The initial products use a 3.5 μm particle for HPLC and will soon use 1.8 μm for UHPLC. The columnsutilize a PEEK-lined stainless‑steel column hardware that minimizes the undesirable surface interactions between samples and steel and achieve the best chromatography performance. They are versatilefor the LC–MS-based analysis of polar compounds in “omics” research, for example, metabolomics,proteomics, glycomics, and lipidomics, in the fields ofclinical diagnostics and pharmaceutical discovery.

The packed iHILIC stationary phases are charge-modulated amide silica particles that are covalently bonded with various neutral, positively charged, and negatively charged hydrophilic functional groups, following the company’s innovative and uniquesurface‑bonding technologies. iHILIC-Fusion is neutral and slightly negatively charged at pH 2–8, while iHILIC-Fusion(+) is constantly slightly positively charged. According to the company, the columns provide customized and complementary selectivity, ultimateseparation efficiency, ultra-low column bleeding, and are particularly suitable for LC–MS applications.

Furthermore, they also simplify method development and improve the productivity and data quality in chemical and biological analysis.

The picture shows you the structure of the new phase iHILIC-(P) Classic .